Recent Publications


2019

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. Sci Signal. 2019 Apr 30;12(579). pii: eaav1439. doi: 10.1126/scisignal.aav1439. PMID: 31040260


2018

CaMKII (Ca(2+)/Calmodulin-Dependent Kinase II) in Mitochondria of Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and Neointima Formation. Nguyen EK, Koval OM, Noble P, Broadhurst K, Allamargot C, Wu M, Strack S, Thiel WH, Grumbach IM
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1333-1345. doi: 10.1161/ATVBAHA.118.310951. PMID: 29599132

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Pennington SM, Klutho PR, Xie L, Broadhurst K, Koval OM, McCormick ML, Spitz DR, Grumbach IM. Redox Biol. 2018 Jun;16:401-413. doi: 10.1016/j.redox.2018.04.001. PMID: 29649787

Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Sebag SC, Koval OM, Paschke JD, Winters CJ, Comellas AP, Grumbach IM. Exp Cell Res. 2018 Jan 15;362(2):400-411. doi: 10.1016/j.yexcr.2017.12.003. PMID: 29225050

Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study. Dogan MV, Grumbach IM, Michaelson JJ, Philibert RA. PLoS One. 2018 Jan 2;13(1):e0190549. doi: 10.1371/journal.pone.0190549. eCollection 2018. PMID: 29293675


2017

The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function. Kulhankova K, Kinney KJ, Stach JM, Gourronc FA, Grumbach IM, Klingelhutz AJ, Salgado-Pabón W. Infect Immun. 2017 Dec 11. pii: IAI.00848-17. doi: 10.1128/IAI.00848-17. PMID: 29229737

Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, Kutschke WJ, Irani K, Lamping KG, Grumbach IM. PLoS One. 2017 Oct 23;12(10):e0186311. doi: 10.1371/journal.pone.0186311. eCollection 2017. PMID: 29059213

Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma. Morris AS, Sebag SC, Paschke JD, Wongrakpanich A, Ebeid K, Anderson ME, Grumbach IM, Salem AK. Mol Pharm. 2017 May 9. doi: 10.1021/acs.molpharmaceut.7b00114.  PMID: 28460526 

Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME and Grumbach IM. JCI Insight. 2017;2(3):e88297. doi:10.1172/jci.insight.88297. PMID: 28194433


2016

Role of CaMKII in Ang-II-dependent small artery remodeling. Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM. Vascul Pharmacol. 2016 Sep 20. pii: S1537-1891(16)30109-4. doi: 10.1016/j.vph.2016.09.007. [Epub ahead of print] PMID: 27658984

CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. Winters CJ, Koval O, Murthy S, Allamargot C, Sebag SC, Paschke JD, Jaffer OA, Carter AB, Grumbach IM. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L86-94. doi: 10.1152/ajplung.00132.2015. PMID: 26545899


2015

Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Klutho PJ, Pennington SM, Scott JA, Wilson KM, Gu SX, Doddapattar P, Xie L, Venema AN, Zhu LJ, Chauhan AK, Lentz SR, Grumbach IM. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2594-604. doi: 10.1161/ATVBAHA.115.305857 PMID: 26449752

Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. J Am Heart Assoc. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949. PMID: 26077587

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model. Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME.
Am J Respir Cell Mol Biol. 2015 Jan;52(1):106-15. doi: 10.1165/rcmb.2013-0519OC. PMID: 24988374


2014

Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis. Zhu LJ, Klutho PJ, Scott JA, Xie L, Luczak ED, Dibbern ME, Prasad AM, Jaffer OA, Venema AN, Nguyen EK, Guan X, Anderson ME, Grumbach IM.
Vascul Pharmacol. 2014 Feb;60(2):75-83. doi: 10.1016/j.vph.2014.01.001. Epub 2014 Jan 10. PMID: 24418021


2013

The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. Scott JA, Klutho PJ, El Accaoui R, Nguyen E, Venema AN, Xie L, Jiang S, Dibbern M, Scroggins S, Prasad AM, Luczak ED, Davis MK, Li W, Guan X, Backs J, Schlueter AJ, Weiss RM, Miller FJ, Anderson ME, Grumbach IM. PLoS One. 2013 Aug 8;8(8):e71550. doi: 10.1371/journal.pone.0071550. eCollection 2013. PMID: 24418021

Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner ML, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, Grumbach IM.
Hypertension. 2013 Aug;62(2):434-41. doi: 10.1161/HYPERTENSIONAHA.113.01508. PMID: 23753415

CaMKII is essential for the proasthmatic effects of oxidation. Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. Sci Transl Med. 2013 Jul 24;5(195):195ra97. doi: 10.1126/scitranslmed.3006135. PMID: 23884469