Recent Publications
2023
The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes. Koval OM, Nguyen EK, Mittauer DJ, Ait-Aissa K, Chinchankar W, Qian L, Madesh M, Dai DF, Grumbach IM.bioRxiv. 2023 Feb 16:2023.02.15.528765. doi: 10.1101/2023.02.15.528765. Preprint.PMID: 36824758.
The BBSome regulates mitochondria dynamics and function. Guo DF, Merrill RA, Qian L, Hsu Y, Zhang Q, Lin Z, Thedens DR, Usachev YM, Grumbach I, Sheffield VC, Strack S, Rahmouni K.Mol Metab. 2023 Jan;67:101654. doi: 10.1016/j.molmet.2022.101654. Epub 2022 Dec 10.PMID: 36513220.
2022
Cardiac Adverse Events Associated With Chemo-Radiation Versus Chemotherapy for Resectable Stage III Non-Small-Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study. Herbach E, O'Rorke MA, Carnahan RM, McDowell BD, Allen B, Grumbach I, London B, Smith BJ, Spitz DR, Seaman A, Chrischilles EA.J Am Heart Assoc. 2022 Dec 6;11(23):e027288. doi: 10.1161/JAHA.122.027288. Epub 2022 Dec 1.PMID: 36453633.
Mitochondrial Ca2+ Uptake Drives Endothelial Injury By Radiation Therapy. Ait-Aissa K, Koval OM, Lindsey NR, Grumbach IM.Arterioscler Thromb Vasc Biol. 2022 Sep;42(9):1121-1136. doi: 10.1161/ATVBAHA.122.317869. Epub 2022 Jul 28.PMID: 35899616.
Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling. Damacena de Angelis C, Endoni BT, Nuno D, Lamping K, Ledolter J, Koval OM, Grumbach IM.J Am Heart Assoc. 2022 Jul 5;11(13):e023912. doi: 10.1161/JAHA.121.023912. Epub 2022 Jun 29.PMID: 35766269.
Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma. Tamplin MR, Wang JK, Vitale AH, Hashimoto R, Garvin MK, Binkley EM, Hyer DE, Buatti JM, Boldt HC, Kardon RH, Grumbach IM.BMC Ophthalmol. 2022 Jun 28;22(1):285. doi: 10.1186/s12886-022-02505-9.PMID: 35765019.
Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma. Tamplin MR, Wang JK, Vitale AH, Hashimoto R, Garvin MK, Binkley EM, Hyer DE, Buatti JM, Boldt HC, Kardon RH, Grumbach IM.BMC Ophthalmol. 2022 Jun 28;22(1):285. doi: 10.1186/s12886-022-02505-9.PMID: 35765019.
Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. McLendon JM, Zhang X, Matasic DS, Kumar M, Koval OM, Grumbach IM, Sadayappan S, London B, Boudreau RL.J Am Heart Assoc. 2022 Jul 5;11(13):e025687. doi: 10.1161/JAHA.122.025687. Epub 2022 Jun 22.PMID: 35730644.
Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma. Binkley EM, Tamplin MR, Vitale AH, Boldt HC, Kardon RH, Grumbach IM.Am J Ophthalmol Case Rep. 2022 Mar 25;26:101508. doi: 10.1016/j.ajoc.2022.101508. eCollection 2022 Jun.PMID: 35392251.
Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice. Tamplin MR, Broadhurst KA, Vitale AH, Hashimoto R, Kardon RH, Grumbach IM.Exp Eye Res. 2022 Mar;216:108952. doi: 10.1016/j.exer.2022.108952. Epub 2022 Jan 17.PMID: 35051429.
2021
What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen PKP, Ouimet M, Sutton NR, Aikawa E.Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2641-2647. doi: 10.1161/ATVBAHA.121.316558. Epub 2021 Sep 22.PMID: 34547925. Review.
2019
Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM. Sci Signal. 2019 Apr 30;12(579). pii: eaav1439. doi: 10.1126/scisignal.aav1439. PMID: 31040260
2018
CaMKII (Ca(2+)/Calmodulin-Dependent Kinase II) in Mitochondria of Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and Neointima Formation. Nguyen EK, Koval OM, Noble P, Broadhurst K, Allamargot C, Wu M, Strack S, Thiel WH, Grumbach IM.
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1333-1345. doi: 10.1161/ATVBAHA.118.310951. PMID: 29599132
Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Pennington SM, Klutho PR, Xie L, Broadhurst K, Koval OM, McCormick ML, Spitz DR, Grumbach IM. Redox Biol. 2018 Jun;16:401-413. doi: 10.1016/j.redox.2018.04.001. PMID: 29649787
Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Sebag SC, Koval OM, Paschke JD, Winters CJ, Comellas AP, Grumbach IM. Exp Cell Res. 2018 Jan 15;362(2):400-411. doi: 10.1016/j.yexcr.2017.12.003. PMID: 29225050
Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study. Dogan MV, Grumbach IM, Michaelson JJ, Philibert RA. PLoS One. 2018 Jan 2;13(1):e0190549. doi: 10.1371/journal.pone.0190549. eCollection 2018. PMID: 29293675
2017
The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function. Kulhankova K, Kinney KJ, Stach JM, Gourronc FA, Grumbach IM, Klingelhutz AJ, Salgado-Pabón W. Infect Immun. 2017 Dec 11. pii: IAI.00848-17. doi: 10.1128/IAI.00848-17. PMID: 29229737
Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, Kutschke WJ, Irani K, Lamping KG, Grumbach IM. PLoS One. 2017 Oct 23;12(10):e0186311. doi: 10.1371/journal.pone.0186311. eCollection 2017. PMID: 29059213
Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma. Morris AS, Sebag SC, Paschke JD, Wongrakpanich A, Ebeid K, Anderson ME, Grumbach IM, Salem AK. Mol Pharm. 2017 May 9. doi: 10.1021/acs.molpharmaceut.7b00114. PMID: 28460526
Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME and Grumbach IM. JCI Insight. 2017;2(3):e88297. doi:10.1172/jci.insight.88297. PMID: 28194433
2016
Role of CaMKII in Ang-II-dependent small artery remodeling. Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM. Vascul Pharmacol. 2016 Sep 20. pii: S1537-1891(16)30109-4. doi: 10.1016/j.vph.2016.09.007. [Epub ahead of print] PMID: 27658984
CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. Winters CJ, Koval O, Murthy S, Allamargot C, Sebag SC, Paschke JD, Jaffer OA, Carter AB, Grumbach IM. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L86-94. doi: 10.1152/ajplung.00132.2015. PMID: 26545899
2015
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Klutho PJ, Pennington SM, Scott JA, Wilson KM, Gu SX, Doddapattar P, Xie L, Venema AN, Zhu LJ, Chauhan AK, Lentz SR, Grumbach IM. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2594-604. doi: 10.1161/ATVBAHA.115.305857 PMID: 26449752
Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function. Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. J Am Heart Assoc. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949. PMID: 26077587
Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model. Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME.
Am J Respir Cell Mol Biol. 2015 Jan;52(1):106-15. doi: 10.1165/rcmb.2013-0519OC. PMID: 24988374
2014
Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis. Zhu LJ, Klutho PJ, Scott JA, Xie L, Luczak ED, Dibbern ME, Prasad AM, Jaffer OA, Venema AN, Nguyen EK, Guan X, Anderson ME, Grumbach IM.
Vascul Pharmacol. 2014 Feb;60(2):75-83. doi: 10.1016/j.vph.2014.01.001. Epub 2014 Jan 10. PMID: 24418021
2013
The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. Scott JA, Klutho PJ, El Accaoui R, Nguyen E, Venema AN, Xie L, Jiang S, Dibbern M, Scroggins S, Prasad AM, Luczak ED, Davis MK, Li W, Guan X, Backs J, Schlueter AJ, Weiss RM, Miller FJ, Anderson ME, Grumbach IM. PLoS One. 2013 Aug 8;8(8):e71550. doi: 10.1371/journal.pone.0071550. eCollection 2013. PMID: 24418021
Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II. Prasad AM, Nuno DW, Koval OM, Ketsawatsomkron P, Li W, Li H, Shen FY, Joiner ML, Kutschke W, Weiss RM, Sigmund CD, Anderson ME, Lamping KG, Grumbach IM.
Hypertension. 2013 Aug;62(2):434-41. doi: 10.1161/HYPERTENSIONAHA.113.01508. PMID: 23753415
CaMKII is essential for the proasthmatic effects of oxidation. Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME. Sci Transl Med. 2013 Jul 24;5(195):195ra97. doi: 10.1126/scitranslmed.3006135. PMID: 23884469